Sanjeevi Sivasankar

Faculty
Ph.D.
Assistant Professor
Biological Systems

A319 Zaffarano Hall
sivasank [at] iastate [dot] edu
515-294-1220


 

ACADEMIC APPOINTMENTS

  1. 2008-Present: Assistant Professor, Department of Physics and Astronomy, Iowa State University
  2. 2008-Present: Associate Scientist, Ames Laboratory, United States Department of Energy
  3. 2008-Present: Courtesy Assistant Professor, Department of Electrical and Computer Engineering, Iowa State University
  4. 2007-2008: Associate Specialist, University of California, Berkeley, Advisor: Prof. Steven Chu (co-winner of 1997 Nobel Prize in Physics)

 

ACADEMIC PREPARATION

  1. 2001-2007: Postdoctoral Fellowship, Department of Physics, Stanford University, Advisor: Prof. Steven Chu (co-winner of 1997 Nobel Prize in Physics)
  2. 1995-2001: Ph.D., Biophysics, University of Illinois at Urbana-Champaign Advisor: Prof. Deborah Leckband
  3. 1993-1995: M.Sc., Biophysics, All India Institute of Medical Sciences, India
  4. 1990-1993: B.Sc. (Hons), Biophysics, All India Institute of Medical Sciences, India

 

PUBLICATIONS
Legend: +Corresponding author, *equal contribution

  1. Lowndes, M., Rakshit, S., Shafraz, O., Borghi, N., Harmond, R., Green, K., Sivasankar, S., Nelson, W.J., (2014) Distinguishing roles of different cadherins in the assembly and structural integrity of the desmosome complex, J. Cell Sci. (In Press).
  2. Rakshit, S., Sivasankar., S.+, (2014) Biomechanics of cell adhesion: How force regulates the lifetime of adhesive bonds at the single molecule level, Phys. Chem. Chem. Phys., 16, 2211-2223
  3. Sivasankar, S.+, (2013) Tuning the kinetics of cadherin adhesion, J Invest. Dermatol., 133, 2318-2323
  4. Rakshit, S., Zhang, Y.X., Manibog, K., Shafraz, O., Sivasankar., S.+, (2012) Ideal, catch and slip bonds in cadherin adhesion, Proc. Natl. Acad. Sci. USA, 109, 18815-18820
  5. Li, H.*, Yen, C.F.*, Sivasankar, S.+, (2012) Fluorescence Axial Localization with Nanometer Accuracy and Precision, Nano Lett., 12, 3731-3735
  6. Leckband, D., Sivasankar, S., (2012) Cadherin recognition and adhesion, Curr. Opin. Cell Biol., 24, 1-8.
  7. Choi, C.L., Li, H., Olson, A.C.K., Jain, P.K., Sivasankar, S.+, Alivisatos, A.P.+, (2011) Spatially indirect emission in a luminescent nanocrystal molecule, Nano Lett., 11, 2358-2362
  8. Li, H., Fowler, N., Struck, C., Sivasankar., S.+, (2011) Flow triggered by instabilities at the contact-line of a drop containing nanoparticles, Soft Matter, 7, 5116-5119
  9. Rakshit, S., and Sivasankar, S.+, (2011) Cross-linking of a charged polysaccharide using polyions as electrostatic staples, Soft Matter, 7, 2348-2351
  10. Choi, C.L., Koski, K.J., Sivasankar, S., Alivisatos, A.P., (2009) Strain-Dependent Photoluminescence Behavior of CdSe/CdS Nanocrystals with Spherical, Linear, and Branched Topologies, Nano Lett., 9, 3544-3549
  11. Sivasankar, S.*+, Zhang, Y.*, Nelson,W.J., and Chu, S.+, (2009) Characterizing the initial encounter complex in cadherin adhesion, Structure, 17, 1-7 (Selected for an editor’s choice preview: Structure, (2011) 1035-1036)
  12. Sivasankar, S.+ and Chu, S., (2009) Nanoparticle mediated non-fluorescent bonding of microspheres to atomic force microscope cantilevers and imaging fluorescence from bonded cantilevers with single molecule sensitivity, Nano Lett., 9, 2120-2124
  13. Zhang, Y.*, Sivasankar, S.*+, Nelson,W.J., and Chu, S.+, (2009) Resolving cadherin interactions and binding cooperativity at the single molecule level, Proc. Natl. Acad. Sci. USA, 106, 109-114
  14. Sivasankar, S., and Chu, S., (2007) Optical bonding using silica nanoparticle sol-gel chemistry, Nano Lett., 7, 3031-3034
  15. Sivasankar, S., Gumbiner, B., and Leckband, D., (2001) Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains, Biophys. J., 80, 1758-1768
  16. Leckband, D., and Sivasankar, S., (2000) Mechanism of homophilic cadherin adhesion, Curr. Opin. Cell Biol., 12, 587-592 
  17. Leckband, D., and Sivasankar, S., (1999) Forces controlling protein interactions: theory and experiment, Colloids and Surfaces B: Biointerfaces,  14, 83-97
  18. Sivasankar, S., Brieher, W., Lavrik, N., Gumbiner, B., and Leckband, D., (1999) Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains, Proc. Natl. Acad. Sci. USA, 96, 11820-11824
  19. Sivasankar, S., Subramaniam, S., and Leckband, D., (1998) Direct molecular level measurements of the electrostatic properties of a protein surface, Proc. Natl. Acad. Sci. USA, 95, 12961-12966

 

BOOK CHAPTERS

  1. Leckband, D., Sivasankar, S., (2012) Biophysics of cadherin adhesion, Springer: Sub-cellular Biochemistry, Volume: 60, Pages: 63-88.

 

PATENTS

  1. Sivasankar, S., and Chu, S., Methods of bonding optical structures, bonding and silylation of optical structures, bonded optical structures, and silylated bonded optical structures, United States Patent 8,123,898.
  2. Choi, C.L., Koski, K.J., Sivasankar, S., Alivisatos, A.P., Systems and Methods of Detecting Force and Stress Using Tetrapod Nanocrystal, United States Patent 8,513,624.
  3. Sivasankar, S., and Li, H., System, apparatus, and method for simultaneous single molecule Atomic Force Microscopy and fluorescence measurements, (Patent Pending).
  4. Li, H., Yen, C.F., and Sivasankar, S., Fluorescence axial localization with nanometer accuracy and precision, (Patent Pending).